Metamizole (INN), or dipyrone, is an analgesic (pain reliever) and antipyretic (fever reducer). Metamizole sodium is marketed under various trade names, including Algozone, Algocalmin, Algopyrin, Analgin, Dipirona, Novalgin, Neo-Melubrina and Optalgin. Metamizole was first synthesized by the German companyHoechst AG (now part of Sanofi) in 1920, and its mass production started in 1922. It remained available worldwide until the 1970s, when it was linked with a small risk of causing agranulocytosis, a potentially fatal condition. Those results have been disputed in meta-analyses conducted in the 2000s.Regardless, several national medical authorities have withdrawn metamizole from the market altogether or have restricted it to be available only with a prescription, although it remains available over the counter in many countries.
Analgin (Metamizole Sodium), common Medicare prescription drugs. Compound aminopyrine and sodium sulfite combining soluble in water, antipyretic, analgesic effect than aminopyrine fast and strong.
Analgin is a non-steroidal antiinflammatory drug that potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX.
Function
1. The anti-inflammatory effect of the pharmacological action is strong and fast, and also has a certain anti-inflammatory and anti-rheumatic effects, and also has a certain effect on gastrointestinal smooth muscle spasm. Good solution effect.
2. Suitable for antipyretic, analgesic and anti-rheumatic. Also used for intestinal fistula And the intestinal swollen gas is embolized.
Application
1.Dipyrone is Antipyretic analgesics of Pyrazolones.
2.It indicated for treatment diseases caused by high fever and various pain.
3.It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal ect.
4.It is freely soluble in water and rapidly effect. It is prepared ampoules .
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